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Wound remodeling
During remodeling, no net increase in collagen occurs but wound tensile strength increases greatly. Why?
- Initial wound healing is notable for production of large amounts of randomly oriented collagen.
- During remodeling, this collagen becomes cross-linked and replaced with more organized collagen that is better arranged to resist mechanical stress.
- Like raw wool being woven into strong yarn, the remodeled collagen is compacted into fibers that are many times stronger than random collagen fibrils.
- However, the final strength of the new collagen never reaches the strength of uninjured collagen.
