Why does intraosseous infusion work?
The bone marrow serves as a “stiff” vascular bed. It is composed of interconnected sinusoids that are fed and drained by veins that traverse the cortex of the bone and connect with the central circulation. Fluids infused anywhere into the marrow cavity enter these vascular channels and find their way to the central venous system. In animal models, transit times from the tibia to the heart are short (less than 60 seconds). Numerous medications and fluids have been shown to be effective when administered via this route.
