Which diseases commonly coexist in patients with Relapsing Polychondritis?
Roughly one in three patients with RPC have (at the time of their diagnosis) or will develop an associated disease, with vasculitis and MDS most commonly identified.
Most rheumatologic diseases have been reported in association with RPC as well.
The inflammatory rheumatologic diseases typically precede the onset of RPC. MDS commonly occurs before or simultaneously with RPC, leading some to hypothesize that RPC in this setting may represent a paraneoplastic phenomenon.
| Medical Conditions Associated with RPC | |
|---|---|
| Systemic vasculitis | Behçet’s (MAGIC syndrome), GPA, PAN, EGPA |
| Rheumatologic conditions | SLE, RA, Sjogrens, spondyloarthritis, SSc |
| Organ-specific autoimmune conditions | Autoimmune thyroiditis, Type I diabetes, IBD, myasthenia gravis, PBC |
| Hematologic disorders | MDS, lymphomas, ALL, and other myeloproliferative disorders |
ALL, acute lymphoblastic leukemia; EGPA, eosinophilic granulomatosus with polyarteritis; GPA, granulomatosus with polyarteritis; IBD, inflammatory bowel disease; MDS, myelodysplastic syndrome; PAN, polyarteritis nodosa; PBC, primary biliary cholangitis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SSc, systemic sclerosis.
