Which clinical and laboratory manifestations that can occur in APS are not included in the updated APS criteria?
• Clinical: valvular heart disease, certain neurologic manifestations (chorea, seizures, cognitive dysfunction), nephropathy (acute thrombotic, chronic vaso-occlusive), dermatologic (livedo reticularis, livedoid vasculopathy), pulmonary (hypertension due to microvascular disease, diffuse alveolar hemorrhage [DAH], fibrosing alveolitis), avascular necrosis, and hematologic (thrombocytopenia or hemolytic anemia either immune-mediated or due to thrombotic microangiopathy).
• Laboratory: IgA aCL abs or IgA anti-β2GPI abs; anti-domain I-β2GPI ab; antibodies against other candidate antigens (annexin, PS/PT, protein C/S, vimentin/cardiolipin complex, others).
