When do fetal losses typically occur in patients with Antiphospholipid Antibodies

When do fetal losses typically occur in patients with Antiphospholipid Antibodies?

Up to 2% of normal pregnant women have aPL abs, whereas 15% to 20% of women with recurrent pregnancy losses or pregnancy complications due to placental ischemia have these antibodies. The pregnancy is usually lost before the 10th week. The proposed pathogenesis is that anti-β2GPI antibodies bind to β2GPI bound to the anionic phospholipid membrane of trophoblasts. This binding leads to complement fixation, complement split product (C5a) release, and influx of inflammatory cells causing a prothrombotic state. Anti-β2GPI antibodies bound to trophoblasts can also alter adhesion molecule expression and downregulates human chorionic gonadotropin, prolactin, and insulin-like growth factor-binding protein-1 secretion leading to inadequate trophoblastic invasion.

Patients with aPL abs are also at risk for later obstetric complications including preeclampsia, fetal death after 10th week, intrauterine growth restriction, and preterm labor. These manifestations are due to placental insufficiency from thrombosis causing placental infarcts.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856