What is metabolic acidosis

What is metabolic acidosis?

A metabolic acidosis is a metabolic process resulting in increased [H + ]; there are two main etiologies:

A. The addition of an acid (shift in equation 1 from left to right).Buffer systems to remove a H load.Although equations 2 and 3 describe buffer systems to remove H in terms of chemistry of this process, there is a different emphasis in physiologic terms. In this context, flux through equation 2 must be minimized. This occurs if these added H are forced to bind to bicarbonate (HCO − ) by lowering the PCO in capillaries of skeletal muscles (equation 3) where this buffer system is most abundant, thereby pulling equation 3 to the right, which lowers the concentration of H in plasma and minimizes binding of H to intracellular proteins in vital organs (e.g., brain and heart).

B. The loss of HCO , usually with sodium (Na ) (NaHCO ), or potassium (K ), or both, shift in equation 3 from right to left).

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