What drugs are active at serotonergic synapses?
- Selective serotonin reuptake inhibitors act on SERT.
- Haloperidol, quetiapine, and trazodone are selective agonists for the 5HT 1A receptor but antagonize 5HT 2A . LSD agonizes the 5HT 2A receptor.
- Ergotamine and the triptans act on the 5HT 1B and the 5HT 1D receptors.
- 5-HT 3 receptor antagonists, such as ondansetron, and 5-HT 4 receptor agonists, such as metoclopramide, have both peripheral and central actions and suppress nausea/vomiting.
