Treatment strategies for fluctuations in Parkinsons Disease
What are some of the strategies useful in the management of fluctuations in Parkinsons Disease?
The concept of continuous dopaminergic stimulation has been used as a guiding principle in the prevention and treatment of motor fluctuations.
Strategies designed to achieve this goal include the use of catechol- O -methyltransferase (COMT) inhibitors, such as entacapone, MAO inhibitors such as selegiline and rasagiline, dopamine agonists, and STN deep brain stimulation (DBS).
