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What is the Treatment for Periodic paralysis disorders?
Acetazolamide and dichlorphenamide, both of which are carbonic anhydrase inhibitors, are effective in some patients with each form of Periodic paralysis disorders.
In patients with hypokalemic Periodic paralysis disorders, potassium-sparing diuretics such as spironolactone and triamterene might be used in addition to oral potassium supplements and a low-carbohydrate and low-sodium diet.
Beta-adrenergic agents or ingestion of a high-carbohydrate, low-potassium diet may alleviate the attacks in hyperkalemic Periodic paralysis disorders.
Antiarrhythmics, beta-blockers, or cardioverter-defibrillators should be considered in ATS.
Sources
Osborne RJ, Lin X, Welle S et al.: Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy. Human Mol Genet 18:1471-1481, 2009.
Saperstein DS: Muscle channelopathies. Semin Neurol 28:168-184, 2008.
