Storage and Deposition Diseases
- 1. Musculoskeletal effects can be the presenting manifestation in up to 33% of patients with hemochromatosis.
- 2. Symmetric degenerative arthritis of the second and third metacarpal joints and radiocarpal joints suggests hemochromatotic arthropathy.
- 3. Wilson disease should be considered in patients with the triad of liver disease, neurolgic disease, and a noninflammatory arthropathy of the metacarpophalangeal joints (MCPs) and wrists.
- 4. Ochronotic arthropathy commonly causes severe lumbar spine osteoarthritis with disc space calcifications and vacuum discs.
