Significance of Campylobacter jejuni infection in GBS

What is the significance of Campylobacter jejuni infection in GBS? 

Most patients (75%) with Guillain Barre syndrome and a preceding C. jejuni infection present with AIDP and often the axonal form.

Not all patients with serologic evidence of C. jejuni have gastrointestinal symptoms before the onset of GBS.

Cross-reactivity due to molecular mimicry between antigens from C. jejuni and various peripheral nerve gangliosides may explain the pathogenetic connection between the infection and GBS.


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