What roles do platelet derived growth factor and transforming growth factor beta play in wound healing?
- Platelet-derived growth factor (PDGF) is released initially by platelets in the inflammatory phase during the formation of the initial thrombus.
- It is an important chemoattractant and activator of macrophages, which arrive to orchestrate wound healing.
- These macrophages then secrete additional growth factors that include more PDGF.
- These growth factors attract, recruit, and activate additional macrophages.
- Transforming growth factor beta (TGF-β) is released by macrophages and platelets.
- It is a potent chemoattractant and activator of fibroblasts, stimulating them to form collagen.
- TGF-β is the major growth factor involved in collagen synthesis.
