Risk factors for Tumor lysis syndrome
What are the risk factors for the development of TLS?
Tumor lysis syndrome typically occurs following the chemotherapeutic treatment of hematologic malignancies, in particular Burkitt lymphoma and acute B-cell lymphoblastic leukemia.
Tumor lysis syndrome has only rarely been described following the treatment of solid organ tumors. Specific risk factors for the development of Tumor lysis syndrome include:
- Host-related factors
- • Volume depletion
- • Preexisting kidney disease
- Disease-related factors
- • Large tumor burden, “bulky” disease, or extensive bone marrow involvement
- • High tumor proliferation rate
- • Highly chemo- or radiosensitive tumors
- • Lactate dehydrogenase (LDH) levels greater than 1500 IU (or twice the upper limit of normal)
- • Uric acid level greater than 8.0 mg/dL
