What is neurogenic inflammation?
Neurogenic inflammation refers to the inflammation that is produced by the peripheral release of substances from the nervous system—in particular, from small-diameter primary afferent fibers. Although most studies emphasize the contribution of the primary afferent C fibers, there is also evidence for a contribution of sympathetic postganglionic terminals. The primary afferents release peptides that act on postcapillary venules. These become leaky, resulting in plasma extravasation and vasodilatation. Electrical stimulation of peripheral nerves that have been disconnected from the central nervous system can evoke neurogenic inflammation by antidromic activation of C fibers and the resultant release of neuropeptides in the periphery.