What are the Lab findings of Acute tubulointerstitial nephritis?
- • Azotemia (elevated blood urea nitrogen and serum creatinine)
- • Peripheral eosinophilia
- • Eosinophiluria
- • Sterile pyuria (occasionally, white blood cell [WBC] casts)
- • Microscopic hematuria (very rarely, red blood cell [RBC] casts)
- • Proteinuria (usually <3.5 g/day, with the exception of NSAID-induced ATIN)
- • Renal tubular acidosis (RTA; varies depending on which segment of the renal tubule is affected)
Wu et al. investigated the use of urine biomarkers in the evaluation of drug-induced ATIN and found that urinary monocyte chemotactic peptide-1 (MCP-1) levels showed the closest correlations with interstitial inflammation when compared to other urine biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), a1-microglobulin (a1-MG), and N-acetyl-B-D-glucosaminidase (NAG).
