Lab findings in Eosinophilic Granulomatosis with Polyangiitis
What laboratory abnormalities are seen in Eosinophilic Granulomatosis with Polyangiitis?
The characteristic laboratory abnormality is eosinophilia (>1500 cells/μL). Anemia, elevated ESR/CRP, elevated IgE (70%), and a positive rheumatoid factor (70%) may be found. ANCAs are present in 50% to 65% of patients. These are directed primarily against MPO and give a p-ANCA pattern. Patients who are ANCA-positive are more likely to have or develop renal disease, alveolar hemorrhage, mononeuritis multiplex, and purpura (which are commonly considered vasculitic manifestations). There is no direct correlation between the degree of eosinophilia and disease activity.
