Is there an optimal dosing regimen for CYC

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Is there an optimal dosing regimen for CYC?

  • • Mode of administration of CYC depends on the clinical scenario and clinical judgment.
  • • The two commonly recommended IV regimens are:
    • High dose: Monthly boluses of 0.5–1.0 g/m IV × 6 months
    • Low dose (Euro-Lupus protocol): 500 mg IV every 2 weeks × 6 doses
  • • Low-dose therapy is associated with fewer serious infections and less risk of infertility, but some patients may fail to respond to lower doses
  • • IV dosing regimens (compared with oral) result in a lower total CYC exposure, which is important when considering effects on fertility and bladder toxicity.
  • • Note that the risk of premature ovarian failure correlates with the cumulative dose of CYC (>10–15 g total dose) and the age of the patient (>30 years).
    • • Measurement of anti-Mullerian hormone assesses ovarian reserve can be considered but clinical utility is unclear
  • • For recalcitrant disease, consider rituximab 1 g with CYC 500–750 mg IV followed by the same 14 days later. Response may take months. The CALIBRATE study is investigating this regimen followed by belimumab for Class III/IV nephritis, but the results were not as promising as hoped.

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