What is a hypercoagulable workup?
Family history of clotting, miscarriages, or a paucity of vascular risk factors should raise suspicion for a hypercoagulable state.
Hormone use (oral contraceptives, testosterone replacement, hormone replacement) is associated with an increased thrombotic risk and should be specifically sought from history.
Laboratory tests include antithrombin III, protein C, protein S, activated protein C resistance/factor V Leiden mutation, and prothrombin mutation. Lupus anticoagulant and anticardiolipin or beta2 glycoprotein antibodies point to antiphospholipid antibody syndrome.
Cancer produces a hypercoagulable state, so malignancy evaluation should be considered.
