How is Urticarial Vasculitis treated?
Therapy consists of supportive measures and treatment of any associated or underlying disorder. Assuming that there is no internal organ involvement, conservative treatment is reasonable.
Both H 1 (fexofenadine) and H 2 (ranitidine) antihistamines are used. NSAIDs help with arthralgias and arthritis. In addition, prednisone doses of 10 to 60 mg may be required. Dapsone, hydroxychloroquine, and colchicine may benefit some patients with HUVS.
For patients with severe disease and major organ involvement, cyclophosphamide, rituximab, azathioprine, and mycophenolate mofetil may all be considered alongside prednisone, similar to SLE therapy.
Plasmapheresis followed by intravenous immunoglobulin can be considered for severe, treatment-refractory disease.
