How is HCV associated arthritis different from Rheumatoid Arthritis

How is HCV associated arthritis different from Rheumatoid Arthritis, and how it is treated?

When a patient with HCV infection has a positive RF and a nonerosive, non-nodular polyarthritis in RA distribution for >8 weeks, it can be challenging to differentiate HCV-associated arthritis from RA. However, the presence of anti-CCP antibody and/or erosions on radiograph is indicative of RA. The management of HCV-associated arthritis includes NSAIDs, analgesia and treating the HCV. Resistant cases can be treated with low-dose prednisone and/or hydroxychloroquine, but persistent arthritis despite virologic response to antiviral therapy should prompt consideration of an alternative diagnosis.

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