How is Eosinophilic Granulomatosis with Polyangiitis diagnosed?
EGPA is diagnosed on the basis of its clinical and pathologic features. The diagnosis should be suspected in a patient with a previous history of allergy or asthma who presents with eosinophilia (>1500/μL), and systemic vasculitis involving two or more organs. The diagnosis is corroborated by biopsy of the involved tissue. The major differential diagnosis is idiopathic hypereosinophilic syndrome.