How important is bone marrow biopsy in myeloma with AKI
What is the value of a bone marrow biopsy in patients with myeloma and AKI?
Bone marrow biopsy is performed to confirm marrow involvement by clonally expanded plasma cells and for the determination of cytogenetic abnormalities, which provide important prognostic information regarding treatment and outcome. The bone marrow shows displacement of the normal marrow by plasma cells, which ranges from complete replacement by sheets of tumor cells or as nodular aggregates. The mature plasma cells have eccentric nuclei with “clock-face” chromatin and plentiful cytoplasm, and the immature forms are pleomorphic with abnormal nuclear forms. Immunoperoxidase stains show the tumor cells to stain positive with CD138 and a monoclonal LC restriction
