Histopathologic findings in Eosinophilic Granulomatosis with Polyangiitis
The characteristic pathologic changes in EGPA include small necrotizing granulomas as well as necrotizing vasculitis of small arteries and veins . Granulomas are usually extravascular near the small arteries and veins. They are highly specific and composed of a central eosinophilic core surrounded radially by macrophages and giant cells (in contrast to a granuloma with basophilic core seen in other diseases). Inflammatory cells are also present, with eosinophils predominating with smaller numbers of polymorphonuclear leukocytes and lymphocytes.
