Five factor score in Eosinophilic Granulomatosis with Polyangiitis
The FFS describes five classic features associated with a poor prognosis in EGPA:
• Creatinine >1.58 mg/dL.
• Proteinuria >1 g/day.
• CNS involvement.
• Gastrointestinal involvement.
• Myocardial involvement.
Recently the FFS has been applied to GPA and MPA, but proteinuria has been dropped as a prognostic marker. Using the remaining four FFS indicators, the 5-year survival for patients with any AAV was 91% for FFS of 0, 79% for FFS of 1, and 60% for FFS ≥2.
