Extraarticular manifestations associated with Reactive Arthritis
| Constitutional | Genitourinary |
|---|---|
| Low-grade fever | Infectious urethritis |
| Weight loss (rare) | Sterile urethritis |
| Prostatitis | |
| Ocular | Hemorrhagic cystitis |
| Sterile conjunctivitis (35%) | Salpingitis, vulvovaginitis |
| Anterior uveitis (20%) (acute unilateral, HLA-B27-positive) | Mucocutaneous Circinate balanitis (30%, most frequently associated with Chlamydia ) |
| Keratoderma blennorrhagicum (15%) | |
| Gastrointestinal | Hyperkeratotic nails (10%) |
| Infectious ileitis/colitis | Painless oral ulcers (25%) |
| Sterile ileitis/colitis (60%) | Erythema nodosum ( Yersinia ) |
| Renal | |
| Cardiac (rare in acute disease) | IgA nephropathy |
| Heart block (1%) | Renal amyloidosis |
| Aortic regurgitation | Other |
| Aortitis (1%) | Thrombophlebitis, livedo reticularis |
| Pericarditis (rare) | Neuropathy (cranial or peripheral nerve) |
Note: The frequency of the various extraarticular manifestations depends on both the inciting infectious agent and if the patient is HLA-B27-positive.
