Eosinophilic Granulomatosis with Polyangiitis (EGPA)
Eosinophilic Granulomatosis with Polyangiitis also known as allergic angiitis and granulomatosis of Churg Strauss, is a granulomatous inflammation of small- and medium-sized vessels, frequently involving the skin, peripheral nerves, and lungs, which is associated with peripheral eosinophilia.
It occurs primarily in patients with a previous history of allergic manifestations, such as rhinitis (often with nasal polyps; 70%) and adult-onset asthma (>95%). Cytokines that affect the eosinophil (IL-5) and eosinophil granule proteins (major basic protein, cationic protein) appear to be important in the pathogenesis of this disease.
