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What are the diagnostic criteria for Cerebral Amyloid Angiopathy (CAA)?
Definite Cerebral Amyloid Angiopathy:
- Full postmortem examination demonstrating:
- • Lobar, cortical, or corticosubcortical hemorrhage
- • Severe CAA with vasculopathy
- • Absence of other diagnostic lesion
Probable CAA with supporting pathology:
- Clinical data and pathologic tissue (evacuated hematoma or cortical biopsy) demonstrating:
- • Lobar, cortical, or corticosubcortical hemorrhage
- • Some degree of CAA in specimen
- • Absence of other diagnostic lesion
Probable CAA:
- Clinical data and MRI or CT demonstrating:
- • Multiple hemorrhages restricted to lobar, cortical, or corticosubcortical regions (cerebellar hemorrhage allowed)
- • Age >55 years
- • Absence of other cause of hemorrhage
Possible CAA—clinical data and MRI or CT demonstrating:
- Single lobar, cortical, or corticosubcortical hemorrhage
- Age >55 years
- Absence of other cause of hemorrhage