Diagnostic criteria for Cerebral Amyloid Angiopathy (CAA)

What are the diagnostic criteria for Cerebral Amyloid Angiopathy (CAA)? 

Definite Cerebral Amyloid Angiopathy:

• Full postmortem examination demonstrating:
  • • Lobar, cortical, or corticosubcortical hemorrhage
  • • Severe CAA with vasculopathy
  • • Absence of other diagnostic lesion

Probable CAA with supporting pathology:

• Clinical data and pathologic tissue (evacuated hematoma or cortical biopsy) demonstrating:
  • • Lobar, cortical, or corticosubcortical hemorrhage
  • • Some degree of CAA in specimen
  • • Absence of other diagnostic lesion

Probable CAA:

• Clinical data and MRI or CT demonstrating:
  • • Multiple hemorrhages restricted to lobar, cortical, or corticosubcortical regions (cerebellar hemorrhage allowed)
  • • Age >55 years
  • • Absence of other cause of hemorrhage

Possible CAA—clinical data and MRI or CT demonstrating:

• Single lobar, cortical, or corticosubcortical hemorrhage
• Age >55 years
• Absence of other cause of hemorrhage