What are cryoglobulins?
Cryoglobulins are immunoglobulins (Igs) or Ig-containing complexes that spontaneously precipitate from serum and plasma at low temperatures and become soluble again with rewarming.
Cryoprecipitation of human serum components was first described by Wintrobe and Buell in 1933. The term “cryoglobulin” was introduced by Lerner et al in 1947.
