Clinical Effects of Acromegaly
| CLINICAL EFFECT | CAUSE |
| Coarse features | Periosteal formation of new bone |
| Enlarged hands and feet | Soft tissue hypertrophy |
| Excess sweating | Hypertrophy of sweat glands |
| Deepened voice | Hypertrophy of larynx |
| Skin tags | Hypertrophy of skin |
| Upper airway obstruction and sleep apnea | Hypertrophy of tongue and upper airway |
| Osteoarthritis | Hypertrophy of joint cartilage and osseous overgrowth |
| Carpal tunnel syndrome | Hypertrophy of joint cartilage and osseous overgrowth |
| Hypertension, congestive heart failure | Cardiac hypertrophy |
| Hypogonadism | Multifactorial |
| Diabetes mellitus, glucose intolerance | Insulin antagonism, other factors |
| Colonic polyps | Colonic hypertrophy |
