Clinical clues to the diagnosis of pheochromocytoma

What are some clinical clues to the diagnosis of pheochromocytoma?

• Sustained or paroxysmal hypertension associated with the triad of headache, palpitations, and diaphoresis

• Hypertension and family history of pheochromocytoma

• Refractory hypertension especially if associated with weight loss

• Sinus tachycardia

• Orthostatic hypotension

• Recurrent cardiac dysrhythmias

• Features of MEN type 2 (or 2a) or 3 (or 2b)

• Hypertensive crises during surgery or anesthesia (typically during induction)

• Pressor response to a beta-blocker

• Incidentally discovered adrenal mass

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