autoantibodies seen in patients with selective IgA deficiency without clinically expressed autoimmune disease
Rheumatoid factor and ANA are most consistently observed. Other autoantibodies that may be present include antibodies against double-stranded and single-stranded DNA, cardiolipin, thyroglobulin, thyroid microsomes, smooth muscle, gastric parietal cell, striated muscle, acetylcholine receptor, and bile canaliculi. IgG and IgE autoantibodies against IgA occur in 40% to 60% of patients, which puts them at risk for severe reactions to blood transfusions and intravenous immunoglobulin (IVIG) therapy.
