Autoantibodies in Systemic Lupus Erythematosus and Some of Their Clinical Associations

Autoantibodies in Systemic Lupus Erythematosus and Some of Their Clinical Associations

TargetClinical AssociationsFrequency (%)
dsDNADiagnosis specificity for SLE and correlation with disease activity (especially lupus nephritis activity)50–70
Histones (H1, H2A, H2B, H3, H4)SLE and drug-induced lupus70–100
Sm (SnRNP∗ core proteins B, B’, D, E)High diagnostic specificity for SLE
No correlation with disease activity
20–30
U1-RNP∗ (SnRNP specific proteins A, C, 70-kDa)Mixed connective tissue disease /related overlap syndrome (when not accompanied by anti-Sm antibodies)30–35
Ro/SS-A (60-kDa and 52-kDa proteins)Neonatal lupus (especially if anti-52-kDa)
Photosensitivity, Sjogren’s
Subacute cutaneous lupus NMO-spectrum disorder
30
La/SS-B (48-kDa protein)Neonatal lupus (with anti-SS-A/Ro)
Sjogren’s syndrome
Associated with anti-SS-A/Ro
15
Ribosomal P proteinsHigh diagnostic specificity for SLE
Cytoplasmic staining
Psychiatric disease
15
PhospholipidsInhibition of in vitro coagulation tests (lupus anticoagulant)
Thrombosis
Recurrent abortions/fetal wasting
Neurologic disease (focal presentations)
Thrombocytopenia
30–50
Cell surface antigens• Red blood cells• Platelets• Lymphocytes• Neuronal cells• Hemolytic anemia• Thrombocytopenia• Lymphopenia• Neurologic disease (diffuse presentations)• 5–10• 10–30• 20–80• 30–80

NMO, neuromyelitis optica; RNP, ribonucleoprotein; SLE , systemic lupus erythematosus.

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