Anatomy and functions of Ach in the central nervous system
- Pedunculopontine nuclei (modulation of arousal and sleep states)
- Projections to the neocortex from basal forebrain nuclei (particularly in the nucleus basalis of Meynert, involved in memory/attention, affected early in AD)
- Limbic neurons expressing nAChR are involved in addiction
- Local interneurons in the striatum (regulation of motor activity)
