What drugs have been reported to cause Eosinophilic Granulomatosis with Polyangiitis?
The cysteinyl leukotriene type I receptor antagonists, zafirlukast (Accolate), montelukast (Singulair), and pranlukast, have been associated with EGPA. Whether there is a direct cause is controversial.
Some clinicians believe that EGPA is unmasked when the patient uses these drugs and subsequently tapers their GCs. Others feel that these drugs can directly contribute to the development of EGPA as several patients have developed the disease following drug initiation even when GCs were not tapered. Consequently, leukotriene inhibitors should not be used in patients with EGPA.
