What drugs cause Acute tubulointerstitial nephritis?
The three most common drug classes that cause ATIN are: NSAIDs, proton-pump inhibitors, and antibiotics.
Different drug classes are associated with different manifestations of ATIN.
For example, while beta-lactam antibiotics may be associated with a systemic allergic response (fever, rash, and/or peripheral eosinophilia), NSAID-induced ATIN is not typically associated with extrarenal symptoms.
ATIN secondary to NSAIDs may manifest 6 to 18 months after initiation of the medication. A large percentage of patients with NSAID-induced ATIN have nephrotic syndrome.
Withdrawal of NSAIDs leads to recovery in most cases, though recovery may take up to 12 months.
