What types of urate lowering agents are available?
- • XOIs inhibit uric acid synthesis by inhibiting xanthine oxidase, the final enzyme involved in the production of uric acid . XOIs are first-line ULT.
- • Uricosurics reduce the serum urate concentration by enhancing the renal excretion of uric acid. Typically used as add-on therapy with XOIs.
- • Uricase converts uric acid into allantoin, which is 5 to 10 times more soluble.
