Prazepam

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What is Prazepam

NOTE: This drug is discontinued in the US.

NOTE: Prazepam is a schedule C-IV controlled substance.

Prazepam is an oral benzodiazepine used for the management of symptoms associated with anxiety disorders and for short-term amelioration of the symptoms of anxiety or anxiety associated with depression.

Shorter-duration benzodiazepines are often preferable to prazepam in the treatment of anxiety, particularly in the elderly or patients with liver disease, because prazepam produces an active metabolite with a prolonged half-life. Prazepam was approved by the FDA in 1976.

The Centrax® product was discontinued by the manufacturer in 1996; the FDA subsequently withdrew the NDA for this drug after market removal.

Indications

  • anxiety

For the treatment of anxiety

Side Effects

  1. amnesia
  2. anxiety
  3. ataxia
  4. confusion
  5. depression
  6. dizziness
  7. drowsiness
  8. euphoria
  9. fatigue
  10. headache
  11. insomnia
  12. mania
  13. nightmares
  14. physiological dependence
  15. psychological dependence
  16. syncope
  17. teratogenesis
  18. tolerance
  19. tremor
  20. vertigo
  21. withdrawal

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • benzodiazepine dependence
  • benzodiazepine hypersensitivity
  • breast-feeding
  • children
  • depression
  • geriatric
  • hepatic disease
  • myasthenia gravis
  • Parkinson’s disease
  • porphyria
  • pregnancy
  • psychosis
  • pulmonary disease
  • renal failure
  • renal impairment
  • respiratory depression
  • sleep apnea
  • substance abuse
  • suicidal ideation

Interactions

No information is available regarding drug interactions associated with Prazepam 

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