Polyethylene Glycol and Electrolytes

Polyethylene Glycol and Electrolytes Brand Names

Colyte | GaviLyte-C | GaviLyte-G | GaviLyte-N | GoLYTELY | NuLYTELY | OCL | Suclear | TriLyte

What is Polyethylene Glycol and Electrolytes

Polyethylene glycol and electrolytes are used together primarily for bowel evacuation and cleaning before GI examination.

PEG 3350-electrolytes solutions have been used medicinally for decades. Polyethylene glycol compounds exhibit practically no systemic absorption from the intestine at molecular masses exceeding 3000, and thus act as osmotic laxatives.

Electrolytes are added to the solution to maintain water and electrolyte balance in most patients, even after administration of large volumes.

NuLytely, when compared to GoLytely or CoLyte, contains 52% less sodium and no sodium sulfate; the formula may be more palatable for some patients.

Other than this consideration, the products are interchangeable for therapeutic use.

Indications

  • bowel preparation
  • constipation

For use as a bowel evacuant to clean the colon prior to colonoscopy or barium enema X-ray examination (bowel preparation)

NOTE: Patients should be well hydrated before, during, and after the colon preparation. The first bowel movement should occur approximately 1 hour after the start of solution administration.

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angioedema
  5. arrhythmia exacerbation
  6. atrial fibrillation
  7. chills
  8. colitis
  9. dehydration
  10. diarrhea
  11. dizziness
  12. dyspepsia
  13. dyspnea
  14. fecal incontinence
  15. fecal urgency
  16. fever
  17. fluid retention
  18. GI bleeding
  19. GI perforation
  20. headache
  21. hypernatremia
  22. hypertension
  23. hypocalcemia
  24. hypoglycemia
  25. hypokalemia
  26. hypomagnesemia
  27. hyponatremia
  28. malaise
  29. nausea
  30. palpitations
  31. pancreatitis
  32. peripheral edema
  33. polydipsia
  34. pruritus
  35. pulmonary edema
  36. rash
  37. renal failure (unspecified)
  38. rhinorrhea
  39. seizures
  40. sinus tachycardia
  41. syncope
  42. tremor
  43. urticaria
  44. vomiting

Monitoring Parameters

  • blood glucose
  • serum creatinine/BUN
  • serum electrolytes

Contraindications

  • abdominal pain
  • acute abdomen
  • angina
  • appendicitis
  • breast-feeding
  • cardiac arrhythmias
  • cardiomyopathy
  • children
  • colitis
  • coma
  • dehydration
  • dementia
  • dysphagia
  • electrolyte imbalance
  • esophageal stricture
  • gag reflex depression
  • GI obstruction
  • GI perforation
  • heart failure
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • ileus
  • infants
  • inflammatory bowel disease
  • myocardial infarction
  • neonates
  • pregnancy
  • QT prolongation
  • renal impairment
  • seizure disorder
  • seizures
  • toxic megacolon
  • ulcerative colitis
  • vomiting

Polyethylene glycol; electrolytes solution is contraindicated for use in those with known polyethylene glycol hypersensitivity or with hypersensitivity to any of the components of the specific commercial products.

Interactions

  • Acetaminophen; Hydrocodone
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Benazepril
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Atenolol; Chlorthalidone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Bisacodyl
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bumetanide
  • Calcium Phosphate, Supersaturated
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Casanthranol; Docusate Sodium
  • Castor Oil
  • Chlorothiazide
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Dichlorphenamide
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diuretics
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ethacrynic Acid
  • food
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Indapamide
  • Irbesartan
  • Lactulose
  • Lisinopril
  • Loop diuretics
  • Losartan
  • Methyclothiazide
  • Metolazone
  • Moexipril
  • Nebivolol; Valsartan
  • Nonsteroidal antiinflammatory drugs
  • Olmesartan
  • Perindopril
  • Perindopril; Amlodipine
  • Pimozide
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Quinapril
  • Ramipril
  • Sacubitril; Valsartan
  • Senna
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Spironolactone
  • Stimulant Laxatives
  • Telmisartan
  • Torsemide
  • Trandolapril
  • Trandolapril; Verapamil
  • Triamterene
  • Valsartan
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