Podofilox Brand Name– Condylox
What is Podofilox
Podofilox is a topical mitotic agent for the treatment of external genital and perianal warts (i.e., condylomata acuminata) caused by human papillomavirus (HPV).
The 0.5% topical solution is used to treat external genital warts; the solution is not suitable for use in the perianal area.
Podofilox 0.5% gel may be used to treat external genital or perianal warts. Podofilox is derived from the plant families Coniferae and Berberidaceae (e.g., species of Juniperus and Podophyllum).
Like imiquimod, podofilox can be self-administered by the patient, whereas other treatments for condylomata acuminata (e.g., intralesional interferon alfa, podophyllum resin, trichloroacetic acid) must be administered by a health-care provider.
Podofilox, like other currently available therapies for exophytic genital and perianal warts, does not eradicate HPV or affect the natural history of HPV infection. Despite destruction of HPV warts, latent or subclinical HPV infection can persist and recurrence of visible warts is common.
Condylox topical solution was approved in December 1990.
Condylox gel formulation was approved in March 1997.
Indications
- condylomata acuminata
- human papillomavirus (HPV)
- human papillomavirus (HPV) infection
Side Effects
- bleeding
- dizziness
- dyspareunia
- edema
- erythema
- headache
- hematuria
- insomnia
- nausea
- phimosis
- pruritus
- rash
- skin discoloration
- skin erosion
- skin irritation
- skin ulcer
- vomiting
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- accidental exposure
- breast-feeding
- children
- infants
- ocular exposure
- pregnancy
nteractions
- Imiquimod
- Podophyllum
Imiquimod: (Minor) While no drug interactions have been reported with imiquimod, there is no clinical experience with imiquimod cream therapy immediately following the treatment of genital/perianal warts with other cutaneously applied drugs, such as podofilox. Therefore, imiquimod cream administration is not recommended until skin is healed from any previous topical drug treatments or surgery.
Podophyllum: (Minor) No drug interactions of clinical significance have been noted for podofilox. While no drug interactions have been reported, there is no clinical experience with podofilox immediately following the treatment of genital/perianal warts with other cutaneously applied drugs like podophyllum resin. Therefore, podofilox administration is not recommended until genital and/or perianal tissue is healed from any previous topical drug treatment or surgery
