Phentermine and Topiramate Brand Name– Qsymia
What is Phentermine and Topiramate
Phentermine and Topiramate is a combination product containing an anorectic sympathomimetic amine (phentermine) with topiramate, an antiepileptic drug with weak carbonic anhydrase inhibitor activity whose precise role in weight reduction is not known.
The combination is used as an adjunct to lifestyle modifications for weight loss and chronic weight management in obese adults or overweight adults with at least 1 weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia).
Long-term use of this combination product has been associated with an average weight loss of about 8% to 11%.
Indications
- obesity
- weight management
For the treatment of obesity and for chronic weight management as an adjunct to a reduced-calorie diet and increased physical activity
Side Effects
- alopecia
- anxiety
- back pain
- blurred vision
- bullous rash
- chest pain (unspecified)
- constipation
- cough
- depression
- diarrhea
- dizziness
- dysgeusia
- dysmenorrhea
- dyspepsia
- erythema multiforme
- euphoria
- fatigue
- gastroesophageal reflux
- headache
- hepatic failure
- hepatitis
- hyperammonemia
- hypertension
- hypoesthesia
- hypokalemia
- hypothermia
- impaired cognition
- impotence (erectile dysfunction)
- infection
- influenza
- insomnia
- irritability
- libido decrease
- libido increase
- memory impairment
- metabolic acidosis
- metallic taste
- muscle cramps
- musculoskeletal pain
- myopia
- nasal congestion
- nausea
- nephrolithiasis
- ocular hypertension
- ocular pain
- palpitations
- pancreatitis
- paresthesias
- pemphigus
- pharyngitis
- physiological dependence
- psychological dependence
- psychosis
- rash
- restlessness
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- suicidal ideation
- toxic epidermal necrolysis
- tremor
- urticaria
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- blood glucose
- serum bicarbonate
- serum creatinine/BUN
- serum electrolytes
- weight
Contraindications
- abrupt discontinuation
- alcoholism
- ambient temperature increase
- anorexia nervosa
- anticholinergic medications
- anxiety
- bariatric surgery
- behavioral changes
- breast-feeding
- bulimia nervosa
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- coadministration with other CNS depressants
- contraception requirements
- coronary artery disease
- depression
- diabetes mellitus
- dialysis
- diarrhea
- driving or operating machinery
- emphysema
- ethanol ingestion
- geriatric
- glaucoma
- heart failure
- hepatic disease
- hyperthermia
- hyperthyroidism
- hypokalemia
- increased intraocular pressure
- infants
- insomnia
- labor
- MAOI therapy
- metabolic acidosis
- myocardial infarction
- nephrolithiasis
- obstetric delivery
- pregnancy
- pregnancy testing
- renal disease
- renal failure
- renal impairment
- reproductive risk
- schizophrenia
- seizures
- status asthmaticus
- status epilepticus
- strenuous exercise
- stroke
- substance abuse
- suicidal ideation
- surgery
- thyroid disease
Phentermine; Topiramate is contraindicated in any person with a known hypersensitivity or idiosyncrasy to sympathomimetic amines
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abciximab
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Ambrisentan
- Amifampridine
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminosalicylate sodium, Aminosalicylic acid
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anagrelide
- Anticholinergics
- Antithrombin III
- Anxiolytics; Sedatives; and Hypnotics
- Apixaban
- Aprepitant, Fosaprepitant
- Arformoterol
- Argatroban
- Aripiprazole
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atovaquone; Proguanil
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bethanechol
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bivalirudin
- Boceprevir
- Bosentan
- Bretylium
- Brexpiprazole
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide; Formoterol
- Bumetanide
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Caffeine
- Caffeine; Ergotamine
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbonic anhydrase inhibitors
- Cardiac glycosides
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Citalopram
- Clomipramine
- Clonazepam
- Clonidine
- Clorazepate
- Cobicistat
- Cobimetinib
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conjugated Estrogens; Medroxyprogesterone
- Dabigatran
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desflurane
- Desipramine
- Desirudin
- Desvenlafaxine
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Promethazine
- Diazepam
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Diflunisal
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Dopamine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Doxazosin
- Doxepin
- Doxorubicin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Droxidopa
- Dulaglutide
- Duloxetine
- Dyphylline
- Dyphylline; Guaifenesin
- Edoxaban
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Ephedrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esketamine
- Esmolol
- Esomeprazole; Naproxen
- Estazolam
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Etonogestrel
- Exenatide
- Ezogabine
- Famotidine; Ibuprofen
- Felbamate
- Fenoprofen
- Fentanyl
- Flibanserin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- food
- Formoterol
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Gefitinib
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Halogenated Anesthetics
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyprogesterone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloprost
- Imatinib
- Imipramine
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Indomethacin
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isosulfan Blue
- Ivabradine
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lamotrigine
- Lansoprazole; Naproxen
- Lepirudin
- Leuprolide; Norethindrone
- Levalbuterol
- Levetiracetam
- Levobetaxolol
- Levobunolol
- Levomilnacipran
- Levonorgestrel
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lisdexamfetamine
- Lithium
- Lixisenatide
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lorcaserin
- Low Molecular Weight Heparins
- Lumateperone
- Lurasidone
- Macitentan
- Magnesium Salicylate
- Maprotiline
- Maraviroc
- Mecamylamine
- Meclofenamate Sodium
- Medroxyprogesterone
- Mefenamic Acid
- Mefloquine
- Meglitinides
- Meloxicam
- Meperidine; Promethazine
- Mesoridazine
- Mestranol; Norethindrone
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methysergide
- Metolazone
- Metoprolol
- Midazolam
- Midodrine
- Miglitol
- Milnacipran
- Mirtazapine
- Molindone
- Monoamine oxidase inhibitors
- Nabilone
- Nabumetone
- Nadolol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nisoldipine
- Nitrates
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Norethindrone
- Norgestrel
- Nortriptyline
- Ombitasvir; Paritaprevir; Ritonavir
- Orlistat
- Oxaprozin
- Oxazepam
- Oxycodone
- Ozanimod
- Paroxetine
- Pazopanib
- Pemoline
- Penbutolol
- Pentosan
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phenoxybenzamine
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Pioglitazone
- Pirbuterol
- Piroxicam
- Pramlintide
- Prasugrel
- Prazosin
- Pregabalin
- Probenecid
- Procarbazine
- Prochlorperazine
- Progesterone
- Progestins
- Promethazine
- Propranolol
- Protriptyline
- Quazepam
- Ramelteon
- Rasagiline
- Reserpine
- Rilpivirine
- Riociguat
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Romidepsin
- Rosiglitazone
- Rufinamide
- Safinamide
- Salicylates
- Salmeterol
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Selexipag
- Semaglutide
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Sibutramine
- Simeprevir
- Sodium Oxybate
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Solriamfetol
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfonylureas
- Sulindac
- Tedizolid
- Telithromycin
- Temazepam
- Terazosin
- Terbinafine
- Terbutaline
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiethylperazine
- Thioridazine
- Thrombin Inhibitors
- Thyroid hormones
- Tiagabine
- Ticagrelor
- Ticlopidine
- Timolol
- Tirofiban
- Tolmetin
- Tolterodine
- Tolvaptan
- Torsemide
- Tramadol
- Tranylcypromine
- Treprostinil
- Tretinoin, ATRA
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Trospium
- Ulipristal
- Umeclidinium; Vilanterol
- Valdecoxib
- Valproic Acid, Divalproex Sodium
- Vasodilators
- Vasopressors
- Vemurafenib
- Venlafaxine
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
- Yohimbine
- Zonisamide
