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Pancrelipase Brand Names
Cotazym S | Creon | Creon 10 | Creon 20 | Creon 5 | Dygase | Kutrase | Ku-Zyme | Ku-Zyme HP | Lapase | Lipram | Lipram-CR | Lipram-PN | Lipram-UL | Palcaps | Pancrease | Pancrease MT | Pancreaze | Pancrecarb MS | Pancron | Pangestyme CN | Pangestyme EC | Pangestyme MT | Pangestyme UL | Panocaps | Panocaps MT | Panokae-16 | Panokase | Pertzye | Plaretase | Ultracaps MT | Ultrase | Ultrase MT | Ultresa | Viokace | Viokase | Viokase 16 | Viokase 8 | Zenpep
What is Pancrelipase
Pancrelipase is an oral gastrointestinal agent. It is derived from porcine pancreatic enzymes and contains lipase, amylase, and protease, which are capable of digesting fats, starches, and proteins, respectively.
Pancrelipase has 12 times the lipolytic activity, 4 times the proteolytic activity, and 4 times the amylolytic activity of pancreatin.
Pancreatic enzyme replacement is usually reserved for patients with chronic pancreatic exocrine insufficiency; the enzymes help to re-establish the natural digestive conditions in the intestine and control steatorrhea.
Pancreatic insufficiency products are not clinically interchangeable and are not considered bioequivalent by the FDA.
Indications
- cystic fibrosis
- feeding tube occlusion
- pancreatectomy
- pancreatic insufficiency
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- ascites
- blurred vision
- bronchospasm
- cholecystitis
- cholelithiasis
- constipation
- cough
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- epistaxis
- esophagitis
- fibrosing colonopathy
- flatulence
- gastritis
- GI obstruction
- headache
- hyperglycemia
- hyperuricemia
- hypoglycemia
- infection
- lactose intolerance
- lymphadenopathy
- maculopapular rash
- muscle cramps
- myalgia
- nasal congestion
- nausea
- oral ulceration
- otalgia
- peripheral edema
- pharyngitis
- pruritus
- pruritus ani
- rash
- stomatitis
- urticaria
- vomiting
Monitoring Parameters
- stool exam
Contraindications
- breast-feeding
- diabetes mellitus
- dysphagia
- esophageal stricture
- fibrosing colonopathy
- GI obstruction
- gout
- hyperuricemia
- inflammatory bowel disease
- porcine protein hypersensitivity
- pregnancy
- renal impairment
- surgery
- viral infection
Interactions
- Alpha-glucosidase Inhibitors
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Omeprazole; Sodium Bicarbonate
- Sodium Bicarbonate
