Oxandrolone Brand Name– Oxandrin
What is Oxandrolone
Oxandrolone is an orally-administered synthetic testosterone derivative. Its anabolic effects are greater than its androgenic effects due to the deletion of the methyl group from the C-19 position.
The anabolic potency of oxandrolone is approximately 3 to 13 times that of testosterone and methyltestosterone. In combination with adequate calories, oxandrolone is useful for promoting weight gain after burns or trauma and in certain disease states such as COPD and AIDS.
The increase in weight is primarily a result of enhanced lean body mass as compared to enhanced body fat often seen with nutritional supplementation. The beneficial effects on lean body mass are lost with drug discontinuance.
Oxandrolone is used to help offset protein catabolism associated with prolonged corticosteroid use.
Supportive data also exist for the treatment of patients with Duchenne’s muscular dystrophy, constitutional delay of growth and puberty, HIV wasting syndrome and associated muscle weakness, and short stature associated with Turner’s syndrome.
Conflicting evidence exists as to whether or not anabolic steroids significantly increase athletic performance by increasing muscle strength, but the NCAA and IOC currently prohibit their use by athletes.
Oxandrolone is not ergogenic at labeled doses but athletes often use higher doses; athletic use should be discouraged due to the risk for dyslipidemia, potential hepatotoxicity, and other serious side effects.
Oxandrolone was approved by the FDA in July 1964 and became a controlled substance in 1991.
Indications
- AIDS-associated wasting syndrome
- cachexia
- Duchenne muscular dystrophy
- growth failure
- Turner syndrome
For the treatment of cachexia, and as adjunct therapy to promote weight gain and protein anabolism after weight loss following extensive surgery, chronic infections, severe trauma, or prolonged administration of corticosteroids, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight
Side Effects
- acne vulgaris
- amenorrhea
- bladder discomfort
- cholestasis
- clitoromegaly
- clotting factor deficiency
- coagulopathy
- depression
- elevated hepatic enzymes
- epididymitis
- excitability
- feminization
- fluid retention
- gynecomastia
- hepatic failure
- hepatic necrosis
- hepatitis
- hepatoma
- hirsutism
- hoarseness
- hypercalcemia
- hypercholesterolemia
- hyperkalemia
- hypernatremia
- hyperphosphatemia
- impotence (erectile dysfunction)
- insomnia
- jaundice
- libido decrease
- libido increase
- menstrual irregularity
- new primary malignancy
- oligomenorrhea
- oligospermia
- peliosis hepatis
- penile enlargement
- peripheral edema
- polycythemia
- priapism
- prostatic hypertrophy
- sodium retention
- teratogenesis
- testicular atrophy
- virilization
- weight gain
Monitoring Parameters
- LFTs
Contraindications
- arteriosclerosis
- breast cancer
- breast-feeding
- cardiac disease
- children
- cholestasis
- coronary artery disease
- diabetes mellitus
- geriatric
- heart failure
- hepatic disease
- hepatocellular cancer
- hypercalcemia
- hypercholesterolemia
- jaundice
- myocardial infarction
- peliosis hepatis
- peripheral edema
- polycythemia
- pregnancy
- prostate cancer
- prostatic hypertrophy
- renal disease
Interactions
- Abarelix
- Acarbose
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Betrixaban
- Bivalirudin
- Canagliflozin
- Canagliflozin; Metformin
- Cyclosporine
- Dabigatran
- Dalteparin
- Danaparoid
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darbepoetin Alfa
- Degarelix
- Desirudin
- Dipeptidyl Peptidase-4 Inhibitors
- Edoxaban
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enoxaparin
- Epoetin Alfa
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Fondaparinux
- Glipizide; Metformin
- Glyburide; Metformin
- Goserelin
- Heparin
- Histrelin
- Incretin Mimetics
- Insulins
- Lepirudin
- Leuprolide
- Leuprolide; Norethindrone
- Linagliptin
- Linagliptin; Metformin
- Meglitinides
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methoxy polyethylene glycol-epoetin beta
- Miglitol
- Nafarelin
- Pentosan
- Pramlintide
- Rivaroxaban
- Saw Palmetto, Serenoa repens
- Saxagliptin
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sitagliptin
- Sulfonylureas
- Thiazolidinediones
- Tinzaparin
- Torsemide
- Triptorelin
- Warfarin
