Omadacycline Brand Name– NUZYRA
What is Omadacycline
Omadacycline is an oral and intravenous aminomethylcycline antibiotic within the tetracycline class indicated for the treatment of community-acquired pneumonia (CAP) and acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible organisms in adults.
It is structurally similar to tetracycline class antibacterial agents.
Omadacycline has shown activity against organisms expressing tetracycline-specific resistance mechanisms, including efflux and ribosomal protection.
Like other tetracycline class antibacterial drugs, omadacycline may cause discoloration of deciduous teeth and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.
Indications
- Chlamydophila pneumoniae
- community-acquired pneumonia
- Enterobacter cloacae
- Enterococcus faecalis
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Klebsiella pneumoniae
- Legionella pneumophila
- Mycoplasma pneumoniae
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus lugdunesis
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus intermedius
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- atrial fibrillation
- azotemia
- blurred vision
- candidiasis
- constipation
- diarrhea
- diplopia
- dysgeusia
- dyspepsia
- elevated hepatic enzymes
- enamel hypoplasia
- erythema
- fatigue
- headache
- hyperhidrosis
- hyperphosphatemia
- hypertension
- increased intracranial pressure
- infertility
- injection site reaction
- insomnia
- lethargy
- nausea
- onycholysis
- pancreatitis
- papilledema
- paresthesias
- photosensitivity
- pruritus
- pseudomembranous colitis
- pseudotumor cerebri
- rash
- sinus tachycardia
- spermatogenesis inhibition
- superinfection
- thrombocytosis
- tooth discoloration
- urticaria
- vertigo
- visual impairment
- vomiting
Monitoring Parameters
- CBC with differential
Contraindications
- breast-feeding
- children
- colitis
- contraception requirements
- diarrhea
- geriatric
- GI disease
- increased intracranial pressure
- infants
- infertility
- inflammatory bowel disease
- mortality
- neonates
- papilledema
- pregnancy
- pseudomembranous colitis
- reproductive risk
- sunlight (UV) exposure
- tetracyclines hypersensitivity
- ulcerative colitis
Interactions
- Acitretin
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Carbenicillin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cholestyramine
- Chromium
- Colesevelam
- Colestipol
- Dicloxacillin
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Halobetasol; Tazarotene
- Heparin
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Quinapril
- Insoluble Prussian Blue
- Iron
- Iron Salts
- Iron Sucrose, Sucroferric Oxyhydroxide
- Isotretinoin
- Lanthanum Carbonate
- Leuprolide; Norethindrone
- Levonorgestrel
- Lomitapide
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salts
- Mestranol; Norethindrone
- Methotrexate
- Methoxsalen
- Mipomersen
- Molindone
- Nafcillin
- Neuromuscular blockers
- Norethindrone
- Norgestrel
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oral Contraceptives
- Oxacillin
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Photosensitizing agents (topical)
- Piperacillin
- Piperacillin; Tazobactam
- Polycarbophil
- Polysaccharide-Iron Complex
- Porfimer
- Pyridostigmine
- Quinapril
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- St. John’s Wort, Hypericum perforatum
- Sucralfate
- Sulfonylureas
- Tazarotene
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Tretinoin, ATRA
- Verteporfin
- Warfarin
- Zinc
- Zinc Salts
