Ofloxacin

Ofloxacin Brand Names- Floxin | Ocuflox

What is Ofloxacin

Ofloxacin is an oral, otic, and ophthalmic fluoroquinolone anti-infective. Its half-life is intermediate between norfloxacin and lomefloxacin.

In general, ofloxacin is less potent than ciprofloxacin against most gram-negative bacteria. Disabling and potentially irreversible serious adverse reactions associated with quinolones include tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects.

Other significant adverse events include potential QT prolongation and myasthenia gravis exacerbation.

Ofloxacin is FDA-approved for the treatment of urinary tract infections (UTIs), community-acquired pneumonia, prostatitis, skin and skin structure infections, uncomplicated gonorrhea, nongonococcal urethritis and cervicitis caused by susceptible strains of Chlamydia, and pelvic inflammatory disease.

Ofloxacin is also approved for acute exacerbations of chronic bronchitis and uncomplicated UTIs; however, due to the potential for serious adverse events, quinolones should only be used for these infection types when alternative treatment options cannot be used.

Ofloxacin was FDA-approved in December 1990; an otic formulation was FDA-approved in December 1997

Indications

1. Acinetobacter anitratus
2. Acinetobacter calcoaceticus
3. Acinetobacter lwoffii
4. Aeromonas caviae
5. Aeromonas hydrophila
6. Bacillus anthracis
7. bacterial conjunctivitis
8. Bacteroides fragilis
9. Bacteroides intermedius
10. Bordetella parapertussis
11. Bordetella pertussis
12. bronchitis
13. Campylobacter jejuni
14. cervicitis
15. chlamydia infection
16. Chlamydia trachomatis
17. Chlamydophila pneumoniae
18. Citrobacter diversus
19. Citrobacter freundii
20. Clostridium perfringens
21. community-acquired pneumonia
22. corneal ulcer
23. Corynebacterium diphtheriae
24. cystitis
25. Delftia acidovorans
26. Eikenella corrodens
27. Enterobacter cloacae
28. Enterococcus faecalis
29. epididymitis
30. Escherichia coli
31. Gardnerella vaginalis
32. gonorrhea
33. Haemophilus ducreyi
34. Haemophilus influenzae (beta-lactamase negative)
35. Haemophilus influenzae (beta-lactamase positive)
36. Haemophilus parainfluenzae
37. Hafnia alvei
38. Helicobacter pylori
39. Klebsiella aerogenes
40. Klebsiella oxytoca
41. Klebsiella pneumoniae
42. Legionella bozemanii
43. Legionella dumoffii
44. Legionella gormanii
45. Legionella jordanis
46. Legionella longbeachae
47. Legionella micdadei
48. Legionella pneumophila
49. Legionella wadsworthii
50. Listeria monocytogenes
51. meningococcal infection prophylaxis
52. Moraxella catarrhalis
53. Moraxella lacunata
54. Morganella morganii
55. Mycobacterium avium
56. Mycobacterium intracellulare
57. Mycobacterium tuberculosis
58. Mycoplasma hominis
59. Mycoplasma pneumoniae
60. Neisseria gonorrhoeae
61. Neisseria meningitidis
62. non-gonococcal urethritis (NGU)
63. otitis externa
64. otitis media
65. Pantoea agglomerans
66. Pasteurella multocida
67. pelvic inflammatory disease (PID)
68. Peptococcus niger
69. Peptostreptococcus sp.
70. plague
71. plague prophylaxis
72. Plesiomonas shigelloides
73. Propionibacterium acnes
74. prostatitis
75. Proteus mirabilis
76. Proteus vulgaris
77. Providencia rettgeri
78. Providencia stuartii
79. Pseudomonas aeruginosa
80. Pseudomonas fluorescens
81. Salmonella enteritidis
82. Salmonella typhi
83. Serratia marcescens
84. Shigella sonnei
85. skin and skin structure infections
86. Staphylococcus aureus (MSSA)
87. Staphylococcus captitis
88. Staphylococcus epidermidis
89. Staphylococcus hominis
90. Staphylococcus saprophyticus
91. Staphylococcus simulans
92. Streptococcus agalactiae (group B streptococci)
93. Streptococcus bovis
94. Streptococcus dysgalactiae
95. Streptococcus pneumoniae
96. Streptococcus pyogenes (group A beta-hemolytic streptococci)
97. traveler’s diarrhea
98. typhoid fever
99. Ureaplasma urealyticum
100. urethritis
101. urinary tract infection (UTI)
102. Vibrio cholerae
103. Vibrio parahaemolyticus
104. Viridans streptococci
105. Yersinia enterocolitica
106. Yersinia pestis

Side Effects

1. abdominal pain
2. abnormal dreams
3. agitation
4. agranulocytosis
5. anaphylactic shock
6. anaphylactoid reactions
7. anemia
8. angioedema
9. anxiety
10. aortic dissection
11. aplastic anemia
12. arthralgia
13. asthenia
14. bleeding
15. blurred vision
16. bronchospasm
17. bullous rash
18. candidiasis
19. cardiac arrest
20. chest pain (unspecified)
21. chills
22. coma
23. confusion
24. conjunctivitis
25. constipation
26. cough
27. delirium
28. depression
29. diaphoresis
30. diarrhea
31. diplopia
32. dizziness
33. drowsiness
34. dysesthesia
35. dysgeusia
36. dysmenorrhea
37. dyspepsia
38. dyspnea
39. dysuria
40. edema
41. elevated hepatic enzymes
42. eosinophilia
43. epistaxis
44. erythema multiforme
45. erythema nodosum
46. euphoria
47. exfoliative dermatitis
48. fatigue
49. fever
50. flatulence
51. flushing
52. foreign body sensation
53. glycosuria
54. halitosis
55. hallucinations
56. headache
57. hearing loss
58. hematuria
59. hemolytic anemia
60. hepatic failure
61. hepatic necrosis
62. hepatitis
63. hyperglycemia
64. hypertension
65. hypoesthesia
66. hypoglycemia
67. hyposthenuria
68. hypotension
69. impaired cognition
70. increased intracranial pressure
71. increased urinary frequency
72. insomnia
73. interstitial nephritis
74. jaundice
75. keratitis
76. lacrimation
77. laryngeal edema
78. leukocytosis
79. leukopenia
80. lymphocytosis
81. lymphopenia
82. malaise
83. mania
84. memory impairment
85. menorrhagia
86. myalgia
87. myasthenia gravis
88. nausea
89. neurotoxicity
90. neutropenia
91. nightmares
92. nystagmus
93. ocular irritation
94. ocular pain
95. ocular pruritus
96. otalgia
97. palpitations
98. pancytopenia
99. paranoia
100. paresthesias
101. peripheral neuropathy
102. peripheral vasodilation
103. pharyngitis
104. photophobia
105. photosensitivity
106. pneumonitis
107. polyuria
108. pruritus
109. pseudomembranous colitis
110. pseudotumor cerebri
111. psychosis
112. purpura
113. pyuria
114. QT prolongation
115. rash
116. renal failure (unspecified)
117. respiratory arrest
118. rhabdomyolysis
119. rhinitis
120. rhinorrhea
121. seborrhea
122. seizures
123. serum sickness
124. sinus tachycardia
125. sinusitis
126. skin hyperpigmentation
127. Stevens-Johnson syndrome
128. suicidal ideation
129. superinfection
130. syncope
131. tendinitis
132. tendon rupture
133. thrombocytopenia
134. thrombocytosis
135. thrombotic thrombocytopenic purpura (TTP)
136. tinnitus
137. torsade de pointes
138. toxic epidermal necrolysis
139. tremor
140. urinary retention
141. urticaria
142. vaginal irritation
143. vaginal pain
144. vaginitis
145. vasculitis
146. vertigo
147. vesicular rash
148. visual impairment
149. vomiting
150. weakness
151. weight loss
152. xerophthalmia
153. xerostomia

Monitoring Parameters

• serum creatinine/BUN

Contraindications

• acute myocardial infarction
• aneurysm
• aortic dissection
• apheresis
• arteriosclerosis
• atrial fibrillation
• AV block
• bradycardia
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• celiac disease
• cerebrovascular disease
• children
• colitis
• contact lenses
• corticosteroid therapy
• dehydration
• diabetes mellitus
• diarrhea
• driving or operating machinery
• females
• fever
• geriatric
• GI disease
• heart failure
• hepatic disease
• hepatitis
• hepatotoxicity
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hypertension
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypothermia
• hypothyroidism
• infants
• inflammatory bowel disease
• jaundice
• long QT syndrome
• myasthenia gravis
• myocardial infarction
• neonates
• neurotoxicity
• organ transplant
• peripheral neuropathy
• pheochromocytoma
• pregnancy
• pseudomembranous colitis
• psychiatric event
• QT prolongation
• quinolone hypersensitivity
• renal failure
• renal impairment
• rheumatoid arthritis
• seizure disorder
• sexually transmitted disease
• sickle cell disease
• sleep deprivation
• stroke
• sunlight (UV) exposure
• systemic lupus erythematosus (SLE)
• tendinitis
• tendinopathy
• tendon pain
• tendon rupture
• torsade de pointes
• ulcerative colitis
• viral infection

Interactions

• Abarelix
• Acarbose
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetohexamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Alfuzosin
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Celecoxib
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Apomorphine
• Arformoterol
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Asenapine
• Atomoxetine
• Azithromycin
• Bacillus Calmette-Guerin Vaccine, BCG
• Bedaquiline
• Bepridil
• Betamethasone
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Budesonide
• Budesonide; Formoterol
• Buprenorphine
• Buprenorphine; Naloxone
• Calcium
• Calcium Acetate
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium Chloride
• Calcium Gluconate
• Calcium; Vitamin D
• Canagliflozin
• Canagliflozin; Metformin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Celecoxib
• Ceritinib
• Chloroquine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorpropamide
• Choline Salicylate; Magnesium Salicylate
• Chromium
• Cisapride
• Citalopram
• Clarithromycin
• Class IA Antiarrhythmics
• Clindamycin; Tretinoin
• Clofazimine
• Clomipramine
• Clozapine
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Cortisone
• Crizotinib
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Dasatinib
• Deflazacort
• Degarelix
• Desflurane
• Desipramine
• Deutetrabenazine
• Dexamethasone
• Dextromethorphan; Promethazine
• Diclofenac
• Diclofenac; Misoprostol
• Didanosine, ddI
• Dienogest; Estradiol valerate
• Diflunisal
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Doxepin
• Dronedarone
• Droperidol
• Drospirenone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Dulaglutide
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix; Estradiol; Norethindrone acetate
• Eliglustat
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Encorafenib
• Enflurane
• enteral feedings
• Entrectinib
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esomeprazole; Naproxen
• Estradiol; Levonorgestrel
• Estradiol; Norethindrone
• Estradiol; Norgestimate
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Etodolac
• Exenatide
• Ezogabine
• Famotidine; Ibuprofen
• Fenoprofen
• Fingolimod
• Flecainide
• Fluconazole
• Fludrocortisone
• Fluocinolone; Hydroquinone; Tretinoin
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurbiprofen
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Foscarnet
• Gemtuzumab Ozogamicin
• Gilteritinib
• Glasdegib
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Halobetasol; Tazarotene
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Hetastarch; Dextrose; Electrolytes
• Histrelin
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrocodone; Ibuprofen
• Hydrocortisone
• Hydroxychloroquine
• Hydroxyzine
• Ibuprofen
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Ibutilide
• Iloperidone
• Imipramine
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indomethacin
• Inotuzumab Ozogamicin
• Insulin Aspart
• Insulin Aspart; Insulin Aspart Protamine
• Insulin Degludec
• Insulin Degludec; Liraglutide
• Insulin Detemir
• Insulin Glargine
• Insulin Glargine; Lixisenatide
• Insulin Glulisine
• Insulin Lispro
• Insulin Lispro; Insulin Lispro Protamine
• Insulin, Inhaled
• Insulins
• Iron
• Iron Salts
• Isoflurane
• Isophane Insulin (NPH)
• Itraconazole
• Ivosidenib
• Ketoconazole
• Ketoprofen
• Ketorolac
• Lansoprazole; Naproxen
• Lanthanum Carbonate
• Lapatinib
• Lefamulin
• Lente Insulin
• Lenvatinib
• Leuprolide
• Leuprolide; Norethindrone
• Levalbuterol
• Levomethadyl
• Levonorgestrel
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lithium
• Lixisenatide
• Lofexidine
• Long-acting beta-agonists
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Macimorelin
• Magnesium
• Magnesium Citrate
• Magnesium Hydroxide
• Magnesium Salicylate
• Maprotiline
• Meclofenamate Sodium
• Mefenamic Acid
• Mefloquine
• Meglitinides
• Meloxicam
• Meperidine; Promethazine
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methylprednisolone
• Metronidazole
• Midostaurin
• Mifepristone
• Miglitol
• Mirtazapine
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Nilotinib
• Nonsteroidal antiinflammatory drugs
• Norethindrone
• Norfloxacin
• Norgestrel
• Nortriptyline
• Octreotide
• Olanzapine
• Olodaterol
• Ondansetron
• Oral Contraceptives
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxaprozin
• Ozanimod
• Paliperidone
• Panobinostat
• Pasireotide
• Pazopanib
• Pentamidine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenylephrine; Promethazine
• Pimavanserin
• Pimozide
• Pioglitazone
• Pirbuterol
• Piroxicam
• Pitolisant
• Polycarbophil
• Polysaccharide-Iron Complex
• Porfimer
• Posaconazole
• Pramlintide
• Prednisolone
• Prednisone
• Primaquine
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinapril
• Quinine
• Ranolazine
• Regular Insulin
• Regular Insulin; Isophane Insulin (NPH)
• Repaglinide
• Ribociclib
• Ribociclib; Letrozole
• Rilpivirine
• Risperidone
• Rofecoxib
• Romidepsin
• Rosiglitazone
• Salmeterol
• Saquinavir
• Saxagliptin
• Segesterone Acetate; Ethinyl Estradiol
• Selpercatinib
• Semaglutide
• Sertraline
• Sevelamer
• Sevoflurane
• SGLT2 Inhibitors
• Short-acting beta-agonists
• Simvastatin; Sitagliptin
• Siponimod
• Sitagliptin
• Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Sorafenib
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sucralfate
• Sulfonylureas
• Sulindac
• Sunitinib
• Tacrolimus
• Tamoxifen
• Tazarotene
• Telavancin
• Telithromycin
• Terbutaline
• Tetrabenazine
• Thiazolidinediones
• Thioridazine
• Tiotropium; Olodaterol
• Tolazamide
• Tolbutamide
• Tolmetin
• Tolterodine
• Toremifene
• Trazodone
• Tretinoin, ATRA
• Triamcinolone
• Triclabendazole
• Tricyclic antidepressants
• Trifluoperazine
• Trimipramine
• Triptorelin
• Ultralente Insulin
• Umeclidinium; Vilanterol
• Valdecoxib
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Verteporfin
• Voriconazole
• Vorinostat
• Warfarin
• Zinc
• Zinc Salts
• Ziprasidone