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Nonbiologic immunosuppressive drugs to treat CTD and their potential malignancies
A list of immunosuppressive drugs/agents used in the treatment of connective tissue diseases and their potential malignancies is presented in the below table
Immunosuppressive Drugs/Agents Used in the Treatment of CTD and Their Potential Malignancies
| Treatment | Malignancies |
| Hydroxychloroquine | None |
| Sulfasalazine | None |
| Methotrexate | Small risk for EBV-associated lymphoma |
| Leflunomide | None |
| Azathioprine | Possible risk for non-Hodgkin’s lymphoma |
| Cyclosporine | Risk for EBV-associated lymphoma; skin cancer |
| Mycophenolate mofetil | Possible risk for CNS lymphoma, skin cancer |
| Cyclophosphamide (intravenous) | Small risk for lymphoma or bladder cancer |
| Cyclophosphamide (oral) | Bladder carcinoma (2–4×), non-Hodgkin’s lymphoma, leukemia, skin cancer |
