Nilutamide Brand Name– Nilandron
What is Nilutamide
Nilutamide is an oral, once-a day, antiandrogen for use in combination with orchiectomy for the treatment of metastatic (stage D) prostate carcinoma.
Nilutamide is similar in action to bicalutamide and flutamide but differs from steroidal antiandrogens (e.g., finasteride) in that nilutamide is specific for the androgen receptor.
Compared to placebo, patients experienced improvement in bone pain, longer progression-free survival, and longer median overall survival.
Final FDA approval was granted September 19, 1996.
Indications
- prostate cancer
For the treatment of metastatic prostate cancer in combination with orchiectomy
Side Effects
- abdominal pain
- alopecia
- anemia
- angina
- anorexia
- anxiety
- aplastic anemia
- asthenia
- back pain
- bone pain
- cataracts
- chest pain (unspecified)
- constipation
- cough
- depression
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- fever
- flushing
- GI bleeding
- gynecomastia
- headache
- heart failure
- hematuria
- hepatitis
- hot flashes
- hyperglycemia
- hyperhidrosis
- hypertension
- hypoesthesia
- hypotension
- impotence (erectile dysfunction)
- infection
- influenza
- insomnia
- jaundice
- leukopenia
- libido decrease
- malaise
- melena
- nausea
- nocturia
- paresthesias
- peripheral edema
- photophobia
- pneumonitis
- pruritus
- pulmonary fibrosis
- rash
- rhinitis
- syncope
- testicular atrophy
- visual impairment
- vomiting
- weight loss
- xerostomia
Monitoring Parameters
- chest x-ray
- LFTs
- prostate-specific antigen (PSA)
- pulmonary function tests (PFTs)
Contraindications
- alcoholism
- Asian patients
- breast-feeding
- children
- females
- hepatic disease
- hepatitis
- pneumonitis
- pregnancy
- respiratory insufficiency
- visual disturbance
Interactions
- Ethanol
- Fosphenytoin
- Phenytoin
- Theophylline, Aminophylline
- Warfarin
