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Nepafenac Brand Names- ILEVRO | Nevanac
What is Nepafenac
Nepafenac ophthalmic suspension is a topical non-steroidal anti-inflammatory pro-drug for the treatment of the pain and inflammation associated with cataract surgery.
Nepafenac is the first ophthalmic NSAID pro-drug.
Topical nepafenac readily penetrates the cornea and is then metabolized to amfenac, a potent cyclooxygenase (COX)-1 and COX-2 inhibitor. Topical nepafenac is also hypothesized to be a potential drug to treat ocular neovascularization.
Nepafenac was approved by the FDA on August 19th, 2005.
Indications
- ocular pain
- postoperative ocular inflammation
For the treatment of ocular pain and postoperative ocular inflammation following cataract surgery
Side Effects
- bleeding
- conjunctival hyperemia
- contact dermatitis
- corneal erosion
- edema
- erythema
- foreign body sensation
- headache
- hypertension
- impaired wound healing
- keratitis
- lacrimation
- nausea
- ocular hypertension
- ocular irritation
- ocular pain
- ocular pruritus
- photophobia
- sinusitis
- visual impairment
- vomiting
- xerophthalmia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticoagulant therapy
- asthma
- breast-feeding
- children
- coagulopathy
- contact lenses
- diabetes mellitus
- hemophilia
- infants
- neonates
- NSAID hypersensitivity
- ocular disease
- ocular surgery
- pregnancy
- rheumatoid arthritis
- salicylate hypersensitivity
Interactions
There are no drug interactions associated with Nepafenac products.
