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What is Moxidectin
Moxidectin is an oral anthelmintic indicated as a single dose for the treatment of onchocerciasis due to Onchocerca volvulus in patients age 12 years and older.
Moxidectin treatment does not kill adult O. volvulus and follow-up evaluation is recommended.
The safety and efficacy of repeat administration of moxidectin has not been studied.
The most common adverse reactions associated with moxidectin are related to allergic and inflammatory responses to the death of the microfilariae (the Mazzotti reaction).
These adverse reactions generally occur and resolve in the first week after treatment
Indications
- Onchocerca volvulus
- onchocerciasis
Side Effects
- abdominal pain
- arthralgia
- asthenia
- back pain
- blurred vision
- chills
- conjunctival hyperemia
- conjunctivitis
- cough
- diarrhea
- dizziness
- edema
- elevated hepatic enzymes
- encephalopathy
- eosinophilia
- fever
- foreign body sensation
- headache
- hyperbilirubinemia
- hyperemia
- hyponatremia
- hypotension
- influenza
- lacrimation
- leukocytosis
- lymphadenopathy
- lymphopenia
- musculoskeletal pain
- myalgia
- neutropenia
- ocular pain
- ocular pruritus
- orthostatic hypotension
- paresthesias
- peripheral edema
- photophobia
- proteinuria
- pruritus
- rash
- sinus tachycardia
- urticaria
- visual impairment
Contraindications
- breast-feeding
- Loa loa coinfection
- onchodermatitis
- pregnancy
Interactions
No information is available regarding drug interactions associated with Moxidectin
