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Midodrine Brand Names- Orvaten | ProAmatine
What is Midodrine
Midodrine is an oral prodrug used to treat symptomatic orthostatic hypotension.
It is chemically related to the older drug methoxamine. Midodrine was granted accelerated approval status based on increases in 1-minute standing systolic blood pressure (SBP).
Clinical benefits of midodrine (e.g., improved ability to perform life activities) have not been established, however, standing SBP is considered a surrogate marker which is likely to correspond to a clinical benefit.
In one study of patients with autonomic insufficiency, efficacy of midodrine was superior to that of ephedrine.
Midodrine has also been evaluated in the treatment of urinary and ejaculatory disorders.
Midodrine was FDA approved September 6, 1996, but has been used in other countries for more than 15 years.
Indications
- neurogenic orthostatic hypotension
- orthostatic hypotension
- urinary incontinence
For the treatment of symptomatic orthostatic hypotension, including neurogenic orthostatic hypotension
Side Effects
- abdominal pain
- anxiety
- asthenia
- back pain
- bradycardia
- chills
- confusion
- dizziness
- drowsiness
- dysuria
- erythema multiforme
- flatulence
- flushing
- gooseflesh
- headache
- hyperesthesia
- hypertension
- increased urinary frequency
- insomnia
- nausea
- paresthesias
- pruritus
- pyrosis (heartburn)
- rash
- urinary retention
- urinary urgency
- visual impairment
- xerosis
- xerostomia
Monitoring Parameters
- blood pressure
- LFTs
- serum creatinine/BUN
Contraindications
- breast-feeding
- cardiac disease
- children
- diabetes mellitus
- dialysis
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- MAOI therapy
- pheochromocytoma
- pregnancy
- renal disease
- renal failure
- renal impairment
- thyroid disease
- thyrotoxicosis
- urinary retention
- visual disturbance
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Adefovir
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Ambrisentan
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxapine
- Arformoterol
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Azilsartan; Chlorthalidone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Beta-blockers
- Betaxolol
- Bethanechol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Bretylium
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Caffeine
- Caffeine; Ergotamine
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Carteolol
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cimetidine
- Clonidine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diethylpropion
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxazosin
- Dronabinol
- Dulaglutide
- Dyphylline
- Dyphylline; Guaifenesin
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Entecavir
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Exenatide
- Fexofenadine; Pseudoephedrine
- Fludrocortisone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Ginger, Zingiber officinale
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Green Tea
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Iloprost
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Ionic Contrast Media
- Isocarboxazid
- Labetalol
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lixisenatide
- Loratadine; Pseudoephedrine
- Macitentan
- Maprotiline
- Mecamylamine
- Meglitinides
- Memantine
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methylphenidate
- Methysergide
- Metolazone
- Metoprolol
- Miglitol
- Monoamine oxidase inhibitors
- Nabilone
- Nadolol
- Naproxen; Pseudoephedrine
- Nebivolol
- Nebivolol; Valsartan
- Nicotine
- Nitrates
- Non-Ionic Contrast Media
- Oxytocin
- Ozanimod
- Penbutolol
- Pergolide
- Phendimetrazine
- Phenelzine
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Pioglitazone
- Pirbuterol
- Pramlintide
- Prazosin
- Prilocaine; Epinephrine
- Procainamide
- Procarbazine
- Propofol
- Propranolol
- Pseudoephedrine
- Quinidine
- Racepinephrine
- Ranitidine
- Rasagiline
- Reserpine
- Riociguat
- Rosiglitazone
- Safinamide
- Salmeterol
- Selegiline
- Selexipag
- Semaglutide
- SGLT2 Inhibitors
- Sibutramine
- Solriamfetol
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Terazosin
- Terbutaline
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thyroid hormones
- Timolol
- Tranylcypromine
- Treprostinil
- Triamterene
- Trospium
- Umeclidinium; Vilanterol
- Vasodilators
- Yohimbine
